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Incretin AgonistsRetatrutideRetatrutide (LY3437943) is a synthetic single-molecule triple agonist of the GIP, GLP-1 and glucagon receptors studied in metabolic research on obesity and type 2 diabetes.

Incretin AgonistsCagrilintide (AM833) — a long-acting amylin analogueCagrilintide (AM833, NN0174-0833) is a rationally engineered, lipidated analogue of human amylin (IAPP) with a once-weekly activity profile. This monograph covers its chemistry, mechanism of calcitonin/AMY receptor activation, the preclinical and clinical research record, pharmacokinetics and analytical characterization. Prepared strictly for research use only (RUO).

Incretin AgonistsLiraglutideLiraglutide (Victoza/Saxenda) is an acylated, once-daily GLP-1 analogue. Mechanism of action, pharmacokinetics, and key clinical data with verified sources.

Incretin AgonistsSemaglutideSemaglutide is a long-acting acylated analogue of glucagon-like peptide-1, a GLP-1 receptor agonist that has been the subject of extensive preclinical and clinical research on glycaemic control and body-weight regulation. This overview is strictly scientific and reference in nature.

Incretin AgonistsTirzepatideTirzepatide (LY3298176) is a synthetic peptide, a dual agonist of the GIP and GLP-1 receptors, studied in metabolic research of type 2 diabetes and obesity.